Pathophysiology and medical treatment of pain in fibrous dysplasia of bone
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چکیده
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Pathophysiology and medical treatment of pain in fibrous dysplasia of bone
One of the most common complications of fibrous dysplasia of bone (FD) is bone pain. Usual pain killers are often of inadequate efficacy to control this bone pain. The mechanism of bone pain in FD remains uncertain, but by analogy with bone tumors one may consider that ectopic sprouting and formation of neuroma-like structures by sensory and sympathetic nerve fibers also occur in the dysplastic...
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15 صفحه اولFibrous Dysplasia of Bone
Fibrous dysplasia is a disease which may be manifested in a single bone as tumefaction or a solitary cyst (monostotic type), in a region involving contiguous bones, or in a diffuse manner (polyostotic type), the latter possibly in association with endocrine and developmental disturbances. The condition is of interest to the neurological surgeon when the cranial or cranio-facial structures are i...
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Fibrous dysplasia of bone FD is caused by somatic mutations of the GNAS1. Here, patterns of osteoclastogenesis and bone resorption reflect not only the.FIBROUS DYSPLASIA FD is a sporadic developmental disorder characterized by. Biochemical indices of bone turnover are usually high particularly serum. Osteoclasts within the lesions is slightly higher than normal and the number of.Introduction: F...
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ژورنال
عنوان ژورنال: Orphanet Journal of Rare Diseases
سال: 2012
ISSN: 1750-1172
DOI: 10.1186/1750-1172-7-s1-s3